Sigirr^tm1Lix
Targeted Allele Detail

Summary

• Symbol: Sigirr^tm1Lix
• Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; targeted mutation 1, Xiaoxia Li
• MGI ID: MGI:2675236
• Synonyms: Sigirr^-
• Gene: Sigirr Location: Chr7:140671088-140680485 bp, - strand Genetic Position: Chr7, 86.35 cM
• Alliance: Sigirr^tm1Lix page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85151
• Parent Cell Line: MC50 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 5 were replaced with a neomycin selection cassette inserted by homologous recombination. The insertion of neo was reported to generate stop codons in all three reading frames. Endogenous transcript was undetected by Northern blot analysis of homozygous mutant kidney tissue. (J:85151)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sigirr Mutation: 29 strains or lines available

References

• Original: J:85151 Wald D, et al., SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 2003 Sep;4(9):920-7
• All: 9 reference(s)