Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:8099819 SMXA RI strains were analyzed for 789 polymorphic markers at an average resolution of 4 cM to identify QTLs associated with impaired glucose tolerance. Animals were placed on a high-carbohydrate diet for 11 weeks. Parental strain A/J exhibits a higherbody mass index (BMI) and increased blood glucose concentration at 120 minutes during the intraperitoneal glucose tolerance test (IPTGG) compared to parental strain SM/J. A locus reaching statistical significance for nonfasting glucose concentration mapped to 62 cM on mouse Chromosome 10 with LOD=3.8 at D10Mit136 and is called Nfbg. This locus is also suggestively linked to IPGTT at 120 minutes with LOD=2.6. SM/J-derived alleles appear to confer increased blood glucose concentrations at Nfbg. A possiblecandidate gene for Nfbg is Kcnc2.Several suggestive linkages were also detected on mouse Chromosome 2 for IPTGG at 30 minutes (LOD=2.0 at D2Mit6 with A/J-derived alleles conferring increased blood glucose concentrations), mouse Chromosome 6 for BMI (LOD=3.2 at D6Mit17) and nonfasting blood glucose concentrations (LOD=2.3 at D6Mit287 with A/J-derived alleles conferring increased blood glucose concentrations), and mouse Chromosome 18 for nonfasting blood glucose concentrations (LOD=2.5 at D18Mit20) and fasting blood glucose concentrations (LOD=2.0 at D18Mit17). A/J-derived alleles confer increased blood glucose concentrations at both chromosome 18 loci. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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