T2dm1sa^A/JNshm
QTL Variant Detail

Summary

• QTL variant: T2dm1sa^A/JNshm
• Name: type 2 diabetes mellitus 1 in SMXA RI mice; A/JNshm
• MGI ID: MGI:2675244
• QTL: T2dm1sa Location: Chr10:114758644-114758788 bp Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: A/JNshm

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased blood glucose concentrations compared to SM/J.

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:80998

19 SMXA RI strains were analyzed for 789 polymorphic markers at an average resolution of 4 cM to identify QTLs associated with impaired glucose tolerance. Animals were placed on a high-carbohydrate diet for 11 weeks. Parental strain A/J exhibits a higherbody mass index (BMI) and increased blood glucose concentration at 120 minutes during the intraperitoneal glucose tolerance test (IPTGG) compared to parental strain SM/J.

A locus reaching statistical significance for nonfasting glucose concentration mapped to 62 cM on mouse Chromosome 10 with LOD=3.8 at D10Mit136 and is called Nfbg. This locus is also suggestively linked to IPGTT at 120 minutes with LOD=2.6. SM/J-derived alleles appear to confer increased blood glucose concentrations at Nfbg. A possiblecandidate gene for Nfbg is Kcnc2.

Several suggestive linkages were also detected on mouse Chromosome 2 for IPTGG at 30 minutes (LOD=2.0 at D2Mit6 with A/J-derived alleles conferring increased blood glucose concentrations), mouse Chromosome 6 for BMI (LOD=3.2 at D6Mit17) and nonfasting blood glucose concentrations (LOD=2.3 at D6Mit287 with A/J-derived alleles conferring increased blood glucose concentrations), and mouse Chromosome 18 for nonfasting blood glucose concentrations (LOD=2.5 at D18Mit20) and fasting blood glucose concentrations (LOD=2.0 at D18Mit17). A/J-derived alleles confer increased blood glucose concentrations at both chromosome 18 loci.

References

• Original: J:80998 Kobayashi M, et al., Combinations of nondiabetic parental genomes elicit impaired glucose tolerance in mouse SMXA recombinant inbred strains. Diabetes. 2003 Jan;52(1):180-6
• All: 1 reference(s)