Men1^tm1.2Zqw
Targeted Allele Detail

Summary

• Symbol: Men1^tm1.2Zqw
• Name: multiple endocrine neoplasia 1; targeted mutation 1, Zhao-Qi Wang
• MGI ID: MGI:2675250
• Synonyms: Men1^F
• Gene: Men1 Location: Chr19:6385009-6390921 bp, + strand Genetic Position: Chr19, 4.45 cM, cytoband A
• Alliance: Men1^tm1.2Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85133
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Single loxP sites were left flanking exon 3 after floxed sequence encompassing the neomycin resistance gene and the thymidine kinase gene was removed from Men1^tm1Zqw via expression of cre recombinase in the germline. (J:85133)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Men1^tm1.2Zqw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Men1 Mutation: 40 strains or lines available

References

• Original: J:85133 Bertolino P, et al., Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Cancer Res. 2003 Aug 15;63(16):4836-41
• All: 18 reference(s)