Ptpratm1Sap
Targeted Allele Detail
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| Symbol: |
Ptpratm1Sap |
| Name: |
protein tyrosine phosphatase receptor type A; targeted mutation 1, Jan Sap |
| MGI ID: |
MGI:2675252 |
| Synonyms: |
RPTPalpha- |
| Gene: |
Ptpra Location: Chr2:130292198-130396220 bp, + strand Genetic Position: Chr2, 63.23 cM, cytoband G
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| Alliance: |
Ptpratm1Sap page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:55040
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| Parent Cell Line: |
W4 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 3 was disrupted by the insertion of a beta-galactosidase-neomycin resistance fusion gene preceded by an internal ribosomal entry site (IRES) via homologous recombination. The disrupted exon encoded the extracellular domain. Transcript was undetected by Northern blot analysis of homozygous mutant MEFs. No protien was detected in mutant mice by Western blot analyses using antibodies directed against the entire intracellular domain, the ectodomain, and the C-terminal. Furthermore, evidence of a soluble extracellular domain fragment was undetected.
(J:55040)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ptpra Mutation: |
45 strains or lines available
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| Original: |
J:55040 Su J, et al., Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts. Curr Biol. 1999 May 20;9(10):505-11 |
| All: |
8 reference(s) |
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Analysis Tools
