H2-Oa^tm1Lkar
Targeted Allele Detail

Summary

• Symbol: H2-Oa^tm1Lkar
• Name: histocompatibility 2, O region alpha locus; targeted mutation 1, Lars Karlsson
• MGI ID: MGI:2675254
• Synonyms: H2-O^-, H2-Oa-
• Gene: H2-Oa Location: Chr17:34311314-34314208 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Oa^tm1Lkar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85084
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5' portion of exon 2 was replaced with a neomycin resistance gene inserted by homologous recombination. Protein was undetected in homozygous mutant splenocytes by immunoprecipitation. (J:85084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-Oa Mutation: 11 strains or lines available

References

• Original: J:85084 Liljedahl M, et al., Altered antigen presentation in mice lacking H2-O. Immunity. 1998 Feb;8(2):233-43
• All: 10 reference(s)