Ptx3^tm1Mant
Targeted Allele Detail

Summary

• Symbol: Ptx3^tm1Mant
• Name: pentraxin related gene; targeted mutation 1, Alberto Mantovani
• MGI ID: MGI:2675283
• Synonyms: Ptx3^-
• Gene: Ptx3 Location: Chr3:66127331-66133226 bp, + strand Genetic Position: Chr3, 30.25 cM
• Alliance: Ptx3^tm1Mant page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85080
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was disrupted by the insertion of a cassette containing IRES-lacZ and neo. Transcript was undetected by Northern blot analysis of homozygous mutant heart, skeletal muscle, and liver tissues. (J:85080)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptx3 Mutation: 27 strains or lines available

References

• Original: J:85080 Garlanda C, et al., Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 2002 Nov 14;420(6912):182-6
• All: 37 reference(s)