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Cd59atm1Song
Targeted Allele Detail
Summary
Symbol: Cd59atm1Song
Name: CD59a antigen; targeted mutation 1, Wen-Chao Song
MGI ID: MGI:2675293
Gene: Cd59a  Location: Chr2:103926146-103945699 bp, + strand  Genetic Position: Chr2, 54.53 cM, cytoband E2-E4
Alliance: Cd59atm1Song page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76578
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, which encodes the initiator methionine and the N-terminal signal peptide, was replaced with a neo cassette. Transcript encoding the heart and kidney isoform was undetected in homozygous mutant mice, however truncated transcript similar to the testis-specific isoform was detected. RT-PCR analsysis indicated that the mutant transcript lacked exon 2. The absence of normal protein was confirmed by FACS analysis of erthrocytes obtained from homozygous mutant mice. (J:76578)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cd59a Mutation:  19 strains or lines available
References
Original:  J:76578 Miwa T, et al., Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack. Blood. 2002 May 15;99(10):3707-16
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory