Kcnc3^tm1Echa
Targeted Allele Detail

Summary

• Symbol: Kcnc3^tm1Echa
• Name: potassium voltage gated channel, Shaw-related subfamily, member 3; targeted mutation 1, Emily Chan
• MGI ID: MGI:2675309
• Synonyms: Kv3.3^-
• Gene: Kcnc3 Location: Chr7:44240088-44254178 bp, + strand Genetic Position: Chr7, 28.85 cM
• Alliance: Kcnc3^tm1Echa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71179
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by a PGK-neo cassette inserted by homologous recombination. The deleted region included the start codon. Protein was undetected by Western blot analysis of homozygous mutant mice. (J:71179)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnc3 Mutation: 28 strains or lines available

References

• Original: J:71179 Espinosa F, et al., Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3. J Neurosci. 2001 Sep 1;21(17):6657-65
• All: 14 reference(s)