Pgia28^DBA/2Crl
QTL Variant Detail

Summary

• QTL variant: Pgia28^DBA/2Crl
• Name: proteoglycan induced arthritis 28; DBA/2Crl
• MGI ID: MGI:2675324
• QTL: Pgia28 Location: Chr11:25906097-25906218 bp Genetic Position: Chr11, cM position of peak correlated region/allele: 15.63 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2Crl

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:84150

Linkage analysis was performed on 559 proteoglycan-immunized (BALB/cCrl x DBA/2Crl)F2 animals to detect QTLs associated with arthritis susceptibility, severity, and onset. BALB/cCrl females are 100% susceptible to proteoglycan-induced arthritis (PGIA) whereas DBA/2Crl males are resistant. F1 hybrid males and females are also resistant to PGIA.

Several previously identified PGIA loci were confirmed in this study. These include Pgia1, Pgia4, Pgia6, Pgia7 Pgia8, Pgia9, Pgia12.

Pgia1 mapped to mouse chromosome 1 with LOD=3.1 at D1Mit445 for arthritis severity in male mice. The Pgia1 interval spanned 33-106cM on chr 1.

Pgia4 mapped to mouse chromosome 8 with LOD=3.9 at D8Mit224 for arthritis severity for all F2 mice. The Pgia4 interval spanned 1-22cM on chr8.

Pgia6 mapped to mouse chromosome 10 with LOD=3.5 at D10Mit40 for disease onset in female mice. The Pgia6 interval spanned 30-40cMs on chr 10.

Pgia7 mapped to mouse chromosome 11 with LOD=3.1 at D11Mit132 for disease susceptibility in female mice. The Pgia7 interval spanned 42-70cM on chr 11.

Pgia8 mapped to mouse chromosome 15 with LOD=3.5 at D15Mit252 for arthritis severity in female mice. The Pgia8 interval spanned 0-20cM on chr 15.

Pgia9 mapped to mouse chromosome 15 also, with LOD=3.0 at D15Mit28 for arthritis severity in males. The Pgia9 interval spanned 30-55cM on chr15.

Pgia12 mapped to mouse chromosome 19 with LOD=4.4 at D19Mit30 for disease onset in all F2 mice. The Pgia12 interval spanned 11-33cM on chr 19.

Authors identify novel PGIA loci:

Pgia26 mapped to 52.5 cM on mouse Chromosome 3 with LOD=4.9 at D3Mit158 for arthritis onset in female animals. The Pgia26 QTL interval spans 34 cM - 80 cM on chromosome 3. BALB/cCrl-derived alleles confer high arthritis onset with codominant inheritance at Pgia26.

Pgia27 mapped to 42.5 cM on mouse Chromosome 4 with LOD=3.1 at D4Mit45 for arthritis severity in male animals. The Pgia27 QTL interval spans 35 cM - 45 cM on chromosome 4.

Pgia28 mapped to 14 cM on mouse Chromosome 11 with LOD=2.8 at D11Mit229 for heteroantibody production in male animals. The Pgia28 QTL range spans 0 cM - 28 cM on chromosome 11.

Pgia29 mapped to 45 cM on mouse Chromosome 14 with LOD=2.8 forarthritis severity in male animals andLOD=3.5 for T cell proliferationinfemaleanimals at D14Mit92. The Pgia29 QTL range spans 40 cM - 54 cM on chromosome 14.

References

• Original: J:84150 Adarichev VA, et al., Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun;48(6):1708-20
• All: 1 reference(s)