Rr142^tm1.1Rud
Targeted Allele Detail

Summary

• Symbol: Rr142^tm1.1Rud
• Name: regulatory region 142; targeted mutation 1.1, Frank H Ruddle
• MGI ID: MGI:2675412
• Synonyms: EElox, Hoxc8^tm1.1Rud
• Gene: Rr142 Location: Chr15:102895321-102895520 bp Genetic Position: Chr15, Syntenic
• Alliance: Rr142^tm1.1Rud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85471
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph, Modified regulatory region)
• Mutation: Other
• Mutation details: A hypomorphic allele was generated by deleting the early enhancer (EE) via homologous and cre-mediated recombination. The EE is a 200 bp region approximately 3 kb upstream of the Hoxc8 coding region and contains several putative transcription factor binding sites. This allele differs from Rr142^tm1Rud in that the floxed neo cassette was excised prior to germline transmission, leaving a single loxP site in place of the deleted region. (J:85471)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr142 Mutation: 0 strains or lines available

References

• Original: J:85471 Juan AH, et al., Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer. Development. 2003 Oct;130(20):4823-34
• All: 1 reference(s)