Itga2^tm1Eck
Targeted Allele Detail

Summary

• Symbol: Itga2^tm1Eck
• Name: integrin alpha 2; targeted mutation 1, Beate Eckes
• MGI ID: MGI:2675418
• Synonyms: ITGA2flox
• Gene: Itga2 Location: Chr13:114969617-115068588 bp, - strand Genetic Position: Chr13, 64.61 cM
• Alliance: Itga2^tm1Eck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75683
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1, which is the first coding exon, was flanked by single loxP sites. Western blot anlaysis of lung tissue, spleen tissue, and platelets indicated that the loxP sites did not interfere with protein expression. (J:75683)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga2 Mutation: 80 strains or lines available

References

• Original: J:75683 Holtkotter O, et al., Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem. 2002 Mar 29;277(13):10789-94
• All: 1 reference(s)