Itga2^tm1.1Eck
Targeted Allele Detail

Summary

• Symbol: Itga2^tm1.1Eck
• Name: integrin alpha 2; targeted mutation 1.1, Beate Eckes
• MGI ID: MGI:2675420
• Synonyms: alpha2(-)
• Gene: Itga2 Location: Chr13:114969617-115068588 bp, - strand Genetic Position: Chr13, 64.61 cM
• Alliance: Itga2^tm1.1Eck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75683
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed region including exon 1 was excised from Itga2^tm1Eck via cre-mediated recombination. Protein was undetected in homozygous mutant mice by Western blot anlaysis of lung and spleen tissue and platelets. (J:75683)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga2 Mutation: 80 strains or lines available

References

• Original: J:75683 Holtkotter O, et al., Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem. 2002 Mar 29;277(13):10789-94
• All: 10 reference(s)