Lrig1^tm1Ita
Targeted Allele Detail

Summary

• Symbol: Lrig1^tm1Ita
• Name: leucine-rich repeats and immunoglobulin-like domains 1; targeted mutation 1, Sato Itami
• MGI ID: MGI:2675424
• Synonyms: LIG-1^-
• Gene: Lrig1 Location: Chr6:94581510-94677139 bp, - strand Genetic Position: Chr6, 43.15 cM
• Alliance: Lrig1^tm1Ita page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77286
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette. Neither transcript nor protein was detected in brain tissue of homozygous mutant mice by Northern and Western blot analyses. (J:77286)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrig1 Mutation: 50 strains or lines available

References

• Original: J:77286 Suzuki Y, et al., Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia. FEBS Lett. 2002 Jun 19;521(1-3):67-71
• All: 5 reference(s)