Rapgef1^tm1Mats
Targeted Allele Detail

Summary

• Symbol: Rapgef1^tm1Mats
• Name: Rap guanine nucleotide exchange factor (GEF) 1; targeted mutation 1, Michiyuki Matsuda
• MGI ID: MGI:2675465
• Synonyms: C3G^-
• Gene: Rapgef1 Location: Chr2:29509732-29630376 bp, + strand Genetic Position: Chr2, 20.32 cM, cytoband B
• Alliance: Rapgef1^tm1Mats page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77323
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 15 and 16 were replaced with a neomycin selection cassette inserted by homologous recombination. (J:77323)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef1 Mutation: 192 strains or lines available

References

• Original: J:77323 Ohba Y, et al., Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J. 2001 Jul 2;20(13):3333-41
• All: 1 reference(s)