Traf6^tm1Jino
Targeted Allele Detail

Summary

• Symbol: Traf6^tm1Jino
• Name: TNF receptor-associated factor 6; targeted mutation 1, Jun-ichiro Inoue
• MGI ID: MGI:2675469
• Synonyms: TRAF6-, TRAF6KO
• Gene: Traf6 Location: Chr2:101508774-101532014 bp, + strand Genetic Position: Chr2, 53.9 cM
• Alliance: Traf6^tm1Jino page

Abnormal phenotypes in skin and hair of Traf6^tm1Jino/Traf6^tm1Jino mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77453
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.5 kb genomic fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region corresponded with nucleotides 556 through 865 of the cDNA. Protein was undetected by Western blot analysis of brain lysates obtained from homozygous mutant mice. (J:77453)

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Traf6 Mutation: 34 strains or lines available

References

• Original: J:77453 Naito A, et al., Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells. 1999 Jun;4(6):353-62
• All: 33 reference(s)