Bcl3^tm1Rie
Targeted Allele Detail

Summary

• Symbol: Bcl3^tm1Rie
• Name: B cell leukemia/lymphoma 3; targeted mutation 1, Marc Riemann
• MGI ID: MGI:2675475
• Synonyms: Bcl-3^-
• Gene: Bcl3 Location: Chr7:19542387-19556691 bp, - strand Genetic Position: Chr7, 9.95 cM
• Alliance: Bcl3^tm1Rie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77049
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced sequence encompassing all of exons 3 through 5 and a portion of exon 6. Protein was undetected in homozygous mutant mice by Western blot analysis of spleen whole-cell protein extracts. (J:77049, J:144438)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl3 Mutation: 56 strains or lines available

References

• Original: J:77049 Paxian S, et al., Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3. Gastroenterology. 2002 Jun;122(7):1853-68
• All: 3 reference(s)