Nfkb2^tm1Rsch
Targeted Allele Detail

Summary

• Symbol: Nfkb2^tm1Rsch
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 1, Roland Schmid
• MGI ID: MGI:2675476
• Synonyms: Nf-kb2^-, p52^-
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^tm1Rsch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77049
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.5 kb genomic fragment containing exons 1b through 9 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the initiator methionine and a portion of the Rel homology domain. Protein was undetected in homozygous mutant mice by Western blot analysis of spleen whole-cell protein extracts and a supershift analysis of spleen nuclear extracts. (J:77049)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

References

• Original: J:77049 Paxian S, et al., Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3. Gastroenterology. 2002 Jun;122(7):1853-68
• All: 7 reference(s)