Gas6^tm1Pec
Targeted Allele Detail

Summary

• Symbol: Gas6^tm1Pec
• Name: growth arrest specific 6; targeted mutation 1, Peter Carmeliet
• MGI ID: MGI:2675495
• Synonyms: Gas6^-
• Gene: Gas6 Location: Chr8:13515374-13544490 bp, - strand Genetic Position: Chr8, 6.06 cM
• Alliance: Gas6^tm1Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77462
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Sequences encoding the transcription start site, the start codon, the signal peptide, and the Gla module which is required for binding of the endogenous protein to phospholipid membranes were deleted. Normal transcript was undetected by Northern blot analysis of MEFs derived from homozygous mutant mice, while normal protein was shown to be absent from homozygous mutant kidney extracts by Western blot analysis using an antibody directed against the C-terminal. (J:77462)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gas6 Mutation: 36 strains or lines available

References

• Original: J:77462 Angelillo-Scherrer A, et al., Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med. 2001 Feb;7(2):215-21
• All: 33 reference(s)