Cidea^tm1Pli
Targeted Allele Detail

Summary

• Symbol: Cidea^tm1Pli
• Name: cell death-inducing DNA fragmentation factor, alpha subunit-like effector A; targeted mutation 1, Peng Li
• MGI ID: MGI:2675505
• Gene: Cidea Location: Chr18:67476674-67500855 bp, + strand Genetic Position: Chr18, 39.94 cM
• Alliance: Cidea^tm1Pli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85229
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of intron 1 and the first half of exon 2 was replaced with a neomycin resistance gene in inverse orientation. This results in disruption of the reading frame. Northern blot analysis indicated that no mRNA was produced. (J:85229)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cidea Mutation: 16 strains or lines available

References

• Original: J:85229 Zhou Z, et al., Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 2003 Sep;35(1):49-56
• All: 9 reference(s)