chtl
Spontaneous Allele Detail

Summary

• Symbol: chtl
• Name: chocolate-like
• MGI ID: MGI:2675597
• Gene: chtl Location: Chr7:87143137-97551791 bp Genetic Position: Chr7, Syntenic
• Alliance: chtl page

Mutation origin

• Strain of Origin: B6.129P2-Nos2^tm1Lau/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: The chocolate-like spontaneous mutation was found at The Jackson Laboratory in 1998. A test for allelism to the cht locus demonstrated that the two mutations are in pseudoalleles or that modifier genes in the two background strains can affect the phenotype expression.
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any chtl Mutation: 2 strains or lines available

Notes

A test for allelism with homozygous cht mouse mated to a homozygous mutant mouse produced 32/32 progeny with a dull grey phenotype, unlike cht or a/a . These results suggested chtl is a new allele of the cht gene that produces a different phenotype from the original cht allele. When two matings of the grey color F1s from the allele test progeny were mated together, however, they produced segregating litters for a total of 10 cht looking mice and 3 normal black a/a mice. The appearance of the black mice means either the two mutations are pseudoalleles or modiefier genes can affect the phenotype expresssion.

References

• Original: J:82799 Ward-Bailey PF, et al., Chocolate-like, a spontaneous mutation causing a dark brown coat color in the mouse. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine. MGI Direct Data Submission. 2003
• All: 1 reference(s)