Ncstntm1Jli
Targeted Allele Detail
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Symbol: |
Ncstntm1Jli |
Name: |
nicastrin; targeted mutation 1, Jinhe Li |
MGI ID: |
MGI:2675667 |
Synonyms: |
Nicastrin- |
Gene: |
Ncstn Location: Chr1:171893580-171910356 bp, - strand Genetic Position: Chr1, 79.54 cM
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Alliance: |
Ncstntm1Jli page
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Abnormally segmented somite pairs in Ncstntm1Jli/Ncstntm1Jli mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:85205
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S5/SvEvBrd
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Beginning 3 nucleotides upstream of the translation initiation codon, 1530 bases were replaced with an IRESlacZ/MC1neo cassette. This replaced genomic sequence starting in exon 1 and extending through part of intron 2, deleting the first 63 amino acids of the protein product.
(J:85205)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ncstn Mutation: |
34 strains or lines available
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Original: |
J:85205 Li J, et al., Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model. J Biol Chem. 2003 Aug 29;278(35):33445-9 |
All: |
1 reference(s) |
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