Noxo1^hslt
Spontaneous Allele Detail

Summary

• Symbol: Noxo1^hslt
• Name: NADPH oxidase organizer 1; head slant
• MGI ID: MGI:2675672
• Gene: Noxo1 Location: Chr17:24915208-24919503 bp, + strand Genetic Position: Chr17, 12.49 cM, cytoband A3.3
• Alliance: Noxo1^hslt page

Vestibular defect causing tilting of the head in Noxo1^hslt/Noxo1^hslt mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: SJL.Cg-Thy1^a

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: The molecular lesion in the head slant mouse is a single insertion of a deoxyadenosine residue into exon 1, 28 nucleotides from the start codon. This frameshift mutation is predicted to result in a truncation of the encoded protein after the 34th amino acid. In addition, the transgenic expression of the wild-type gene rescued the defects in the homozygous mutant mouse. (J:106332)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Noxo1 Mutation: 14 strains or lines available

References

• Original: J:86035 Gagnon L, et al., A new spontaneous mutation on Chromosome 17 in the mouse named head slant (hslt). Mouse Mutant Resource Web Site, The Jackson Laboratory, Bar Harbor, Maine. MGI Direct Data Submission. 2003
• All: 2 reference(s)