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Neu1tm1Adz
Targeted Allele Detail
Summary
Symbol: Neu1tm1Adz
Name: neuraminidase 1; targeted mutation 1, Alessandra d'Azzo
MGI ID: MGI:2675708
Synonyms: Neu1 -
Gene: Neu1  Location: Chr17:35150229-35154929 bp, + strand  Genetic Position: Chr17, 18.48 cM
Alliance: Neu1tm1Adz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76937
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ gene and neomycin selection cassette was inserted into the first exon of the gene. Northern blot analysis on RNA derived from various tissues confirmed that all four known transcripts are absent in homozygous mice. (J:76937)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Neu1 Mutation:  26 strains or lines available
References
Original:  J:76937 De Geest N, et al., Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice. Hum Mol Genet. 2002 Jun 1;11(12):1455-64
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
08/02/2024
MGI 6.24
The Jackson Laboratory