Neu1^tm1Adz
Targeted Allele Detail

Summary

• Symbol: Neu1^tm1Adz
• Name: neuraminidase 1; targeted mutation 1, Alessandra d'Azzo
• MGI ID: MGI:2675708
• Synonyms: Neu1 -
• Gene: Neu1 Location: Chr17:35150229-35154929 bp, + strand Genetic Position: Chr17, 18.48 cM
• Alliance: Neu1^tm1Adz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76937
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene and neomycin selection cassette was inserted into the first exon of the gene. Northern blot analysis on RNA derived from various tissues confirmed that all four known transcripts are absent in homozygous mice. (J:76937)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neu1 Mutation: 27 strains or lines available

References

• Original: J:76937 De Geest N, et al., Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice. Hum Mol Genet. 2002 Jun 1;11(12):1455-64
• All: 9 reference(s)