Mpg^tm1Lds
Targeted Allele Detail

Summary

• Symbol: Mpg^tm1Lds
• Name: N-methylpurine-DNA glycosylase; targeted mutation 1, Leona D Samson
• MGI ID: MGI:2675730
• Synonyms: Aag -
• Gene: Mpg Location: Chr11:32176505-32182700 bp, + strand Genetic Position: Chr11, 18.83 cM
• Alliance: Mpg^tm1Lds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77298
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2. Cells derived from homozygous mice have no detectable gene transcripts or 3MeA DNA glycosylase activity. (J:31763)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpg Mutation: 17 strains or lines available

References

• Original: J:77298 Engelward BP, et al., Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13087-92
• All: 21 reference(s)