Syn3^tm1Pggd
Targeted Allele Detail

Summary

• Symbol: Syn3^tm1Pggd
• Name: synapsin III; targeted mutation 1, Paul Greengard
• MGI ID: MGI:2675750
• Synonyms: Syn3^tm1Jfe, synapsin III -
• Gene: Syn3 Location: Chr10:85890989-86334760 bp, - strand Genetic Position: Chr10, 41.95 cM, cytoband C2
• Alliance: Syn3^tm1Pggd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77048
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exon 1. Western blot analysis on brain extracts derived from homozygous mice confirmed that no detectable protein was made from this allele. (J:77048)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Syn3 Mutation: 35 strains or lines available

References

• Original: J:77048 Feng J, et al., Regulation of neurotransmitter release by synapsin III. J Neurosci. 2002 Jun 1;22(11):4372-80
• All: 30 reference(s)