Drd2^tm2Ebo
Targeted Allele Detail

Summary

• Symbol: Drd2^tm2Ebo
• Name: dopamine receptor D2; targeted mutation 2, Emiliana Borrelli
• MGI ID: MGI:2675755
• Synonyms: D2-, D2L -
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm2Ebo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77277
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was replaced with a neomycin selection cassette in order to selectively delete the long isoform of the receptor expressed from this gene. RNAse protection assays demonstrated that the short isoform expression is up-regulated in homozygotes and long isoform expression is undetectable. (J:77277)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:77277 Usiello A, et al., Distinct functions of the two isoforms of dopamine D2 receptors. Nature. 2000 Nov 9;408(6809):199-203
• All: 13 reference(s)