Ctf1^tm1Msd
Targeted Allele Detail

Summary

• Symbol: Ctf1^tm1Msd
• Name: cardiotrophin 1; targeted mutation 1, Michael Sendtner
• MGI ID: MGI:2675769
• Synonyms: ct-1 -
• Gene: Ctf1 Location: Chr7:127311908-127317364 bp, + strand Genetic Position: Chr7, 69.69 cM, cytoband F3
• Alliance: Ctf1^tm1Msd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77294
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment spanning exon 2 and the complete coding region of exon 3. In situ hybridization studies on homozygous embryos demonstrated that no detectable transcript is expressed from this allele. (J:77294)

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctf1 Mutation: 14 strains or lines available

References

• Original: J:77294 Oppenheim RW, et al., Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons. J Neurosci. 2001 Feb 15;21(4):1283-91
• All: 11 reference(s)