Gp6^tm1Ware
Targeted Allele Detail

Summary

• Symbol: Gp6^tm1Ware
• Name: glycoprotein 6 platelet; targeted mutation 1, Jerry Ware
• MGI ID: MGI:2675830
• Synonyms: GP VI^-, GPVI^-
• Gene: Gp6 Location: Chr7:4366964-4400743 bp, - strand Genetic Position: Chr7, 2.52 cM
• Alliance: Gp6^tm1Ware page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85315
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A stop codon and neomycin resistance cassette were inserted in exon 1 immediately 3 prime to the start codon. Platelet lysates from mice homozygous for this mutation lacked protein product as determined immunologically. (J:85315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gp6 Mutation: 19 strains or lines available

Notes

ES cell line = DS2A.

References

• Original: J:85315 Kato K, et al., The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood. 2003 Sep 1;102(5):1701-7
• All: 20 reference(s)