Bad^tm1Sjk
Targeted Allele Detail

Summary

• Symbol: Bad^tm1Sjk
• Name: BCL2-associated agonist of cell death; targeted mutation 1, Stanley J Korsmeyer
• MGI ID: MGI:2675966
• Synonyms: Bad^-
• Gene: Bad Location: Chr19:6919229-6929267 bp, + strand Genetic Position: Chr19, 5.1 cM
• Alliance: Bad^tm1Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84987
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3 kb stretch of DNA containing both exon 3 which contains the BH3 domain and exon 4 which contains the polyadenylation signal was replaced by a neomycin resistance cassette. Western blot analysis demonstrated absence of both the long and the short protein products. (J:84987)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bad^tm1Sjk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bad Mutation: 25 strains or lines available

References

• Original: J:84987 Ranger AM, et al., Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9324-9
• All: 32 reference(s)