Esam^tm1Tq
Targeted Allele Detail

Summary

• Symbol: Esam^tm1Tq
• Name: endothelial cell-specific adhesion molecule; targeted mutation 1, Thomas Quertermous
• MGI ID: MGI:2675994
• Synonyms: ESAM^-, Esam1^-
• Gene: Esam Location: Chr9:37439385-37449615 bp, + strand Genetic Position: Chr9, 20.77 cM, cytoband B
• Alliance: Esam^tm1Tq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85314
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of exon 1, beginning 20 bp upstream of the start codon, was replaced with a cassette containing beta-galactosidase and neomycin resistance genes. Normal transcript was undetected in various tissues including the kidney, heart, and lung of homozygous mutant mice by Northern blot analysis. (J:85314)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esam Mutation: 22 strains or lines available

References

• Original: J:85314 Ishida T, et al., Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. J Biol Chem. 2003 Sep 5;278(36):34598-604
• All: 6 reference(s)