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Ablim1tm1Tili
Targeted Allele Detail
Summary
Symbol: Ablim1tm1Tili
Name: actin-binding LIM protein 1; targeted mutation 1, Tiansen Li
MGI ID: MGI:2676007
Synonyms: abLIM-L -
Gene: Ablim1  Location: Chr19:57021165-57303351 bp, - strand  Genetic Position: Chr19, 52.09 cM
Alliance: Ablim1tm1Tili page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84905
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Modified isoform(s), Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsElimination of the retina-specific L isoform was accomplished by replacing all of exon 1 and 18 bp of intron 1 with a cassette containing IRES-lacZ and MC1-neo. RT-PCR analysis of homozygous mutant mice showed that while transcripts encoding the M and S isoforms were present, transcript encoding the L isoform was absent. Reporter expression was observed but sporadic. (J:84905)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ablim1 Mutation:  56 strains or lines available
References
Original:  J:84905 Lu C, et al., Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein. Neuroscience. 2003;120(1):121-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory