Trim63^tm1Glas
Targeted Allele Detail

Summary

• Symbol: Trim63^tm1Glas
• Name: tripartite motif-containing 63; targeted mutation 1, David J Glass
• MGI ID: MGI:2676048
• Synonyms: MuRF1^-
• Gene: Trim63 Location: Chr4:134042431-134056940 bp, + strand Genetic Position: Chr4, 66.58 cM
• Alliance: Trim63^tm1Glas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77660
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in-frame lacZ gene and neomycin selection cassette replaced approximately 8 kb of gene sequences, including exons 1-4 and most of exon 5. Northern blot analysis on RNA derived from muscle of homozygous mice confirmed that no wild-type transcript is expressed from this allele. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter. (J:77660)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim63 Mutation: 18 strains or lines available

References

• Original: J:77660 Bodine SC, et al., Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001 Nov 23;294(5547):1704-8
• All: 25 reference(s)