Tg(Tyr-HRAS)60Lc
Transgene Detail

Summary

• Symbol: Tg(Tyr-HRAS)60Lc
• Name: transgene insertion 60, Lynda Chin
• MGI ID: MGI:2676096
• Synonyms: Tyr-RAS
• Transgene: Tg(Tyr-HRAS)60Lc Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Tg(Tyr-HRAS)60Lc page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tyr-HRAS)60Lc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HRAS (3265)

  Hras	(MGI:96224)

• Mutation details: The mutant human H-Ras (G12V) has been placed under the control of the tyrosinase promoter and distal enhancer followed by the SV40 splice and polyadenylation sequences. Transgene copy number is low and integration was on the Y chromosome. (J:44088)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tyr-HRAS)60Lc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic animals were produced from two founders, TR39 and TR60, that possessed low transgene copy number and expression level. In TR60, the transgene had inserted into the Y chromosome.

References

• Original: J:44088 Chin L, et al., Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev. 1997 Nov 1;11(21):2822-34
• All: 16 reference(s)