Ndp^tm1Wbrg
Targeted Allele Detail

Summary

• Symbol: Ndp^tm1Wbrg
• Name: Norrie disease (pseudoglioma) (human); targeted mutation 1, Wolfgang Berger
• MGI ID: MGI:2676199
• Synonyms: Norrie
• Gene: Ndp Location: ChrX:16751760-16778013 bp, - strand Genetic Position: ChrX, 12.07 cM
• Alliance: Ndp^tm1Wbrg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30902
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 283 bp fragment spanning the coding portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 56 N-terminal amino acids. (J:30902)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndp Mutation: 8 strains or lines available

References

• Original: J:30902 Berger W, et al., An animal model for Norrie disease (ND): gene targeting of the mouse ND gene. Hum Mol Genet. 1996 Jan;5(1):51-9
• All: 20 reference(s)