Syt7^tm1Nan
Targeted Allele Detail

Summary

• Symbol: Syt7^tm1Nan
• Name: synaptotagmin VII; targeted mutation 1, Norma W Andrews
• MGI ID: MGI:2676220
• Synonyms: Syt VII -
• Gene: Syt7 Location: Chr19:10366454-10430544 bp, + strand Genetic Position: Chr19, 6.58 cM, cytoband B
• Alliance: Syt7^tm1Nan page

Inflammation, injury and fibrosis in skin and skeletal muscle of Syt7^tm1Nan/Syt7^tm1Nan mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85201
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP flanked neomycin resistance cassette replaced most of exon 4 and exon 5. In the process a stop codon was generated in exon 4 after the codon for amino acid 83. Absence of the 1.2kb mRNA for the major isoform of this gene was established by Northern blot analysis. Lack of protein product was confirmed by Western blot analysis. However, a truncated protein may be produced. (J:85201)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syt7 Mutation: 41 strains or lines available

References

• Original: J:85201 Chakrabarti S, et al., Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J Cell Biol. 2003 Aug 18;162(4):543-9
• All: 27 reference(s)