Cd83^tm1Tft
Targeted Allele Detail

Summary

• Symbol: Cd83^tm1Tft
• Name: CD83 antigen; targeted mutation 1, Thomas F Tedder
• MGI ID: MGI:2676282
• Synonyms: CD83^-
• Gene: Cd83 Location: Chr13:43938661-43956608 bp, + strand Genetic Position: Chr13, 21.6 cM, cytoband A4-5
• Alliance: Cd83^tm1Tft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75700
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence fragment extending from within exon 3 through the coding region of exon 5 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 25 residues of the immunoglobulin-like domain and the transmembrane and cytoplasmic domains. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of LPS-stimulated bone marrow-derived dendritic cells. (J:75700)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd83 Mutation: 17 strains or lines available

References

• Original: J:75700 Fujimoto Y, et al., CD83 Expression Influences CD4(+) T Cell Development in the Thymus. Cell. 2002 Mar 22;108(6):755-67
• All: 6 reference(s)