Pitpna^{Gt(OST1152)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Pitpna^{Gt(OST1152)Lex}
• Name: phosphatidylinositol transfer protein, alpha; gene trap OST1152, Lexicon Genetics
• MGI ID: MGI:2676301
• Synonyms: PITPalpha::neo/puro, Pitpna^{Gt(VICTR20)1Vab}
• Gene: Pitpna Location: Chr11:75478923-75519630 bp, + strand Genetic Position: Chr11, 45.92 cM
• Alliance: Pitpna^{Gt(OST1152)Lex} page

Mutation origin

• Mutant Cell Line: OST1152
• Germline Transmission: Earliest citation of germline transmission: J:85204
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector consisting of LTR sites flanking a beta-geo cassette containing a splice acceptor and a PGK-puro cassette containing a splice donor integrated into intron 7. Truncated protein product was undetected by Western blot analysis of homozygous mutant mice. (J:85204)
• Inheritance: Recessive
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST1152	CG473650 ; (MGI Seq Detail)	3' RACE	Chr11:75516292-75517242 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  541 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitpna Mutation: 37 strains or lines available

References

• Original: J:85204 Alb JG Jr, et al., Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia. J Biol Chem. 2003 Aug 29;278(35):33501-18
• All: 2 reference(s)