Tnfrsf18^tm1Ppp
Targeted Allele Detail

Summary

• Symbol: Tnfrsf18^tm1Ppp
• Name: tumor necrosis factor receptor superfamily, member 18; targeted mutation 1, Pier Paolo Pandolfi
• MGI ID: MGI:2676557
• Synonyms: GITR^-, GITR-KO
• Gene: Tnfrsf18 Location: Chr4:156110779-156113351 bp, + strand Genetic Position: Chr4, 87.76 cM, cytoband E
• Alliance: Tnfrsf18^tm1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77393
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 5 were replaced with a neomycin selection cassette inserted by homologous recombination. The absence of normal protein was verified by flow cytometric analysis of T lymphocytes obtained from homozygous mutant mice. (J:77393)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf18 Mutation: 31 strains or lines available

References

• Original: J:77393 Ronchetti S, et al., Role of GITR in activation response of T lymphocytes. Blood. 2002 Jul 1;100(1):350-2
• All: 34 reference(s)