Kcnj9^tm1Kwn
Targeted Allele Detail

Summary

• Symbol: Kcnj9^tm1Kwn
• Name: potassium inwardly-rectifying channel, subfamily J, member 9; targeted mutation 1, Kevin Wickman
• MGI ID: MGI:2676585
• Synonyms: GIRK3 KO
• Gene: Kcnj9 Location: Chr1:172148075-172156889 bp, - strand Genetic Position: Chr1, 79.66 cM
• Alliance: Kcnj9^tm1Kwn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77047
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site remained in place of exon 3 after the cre-mediated excision of a floxed region containing exon 3 and an inserted neo cassette. The deleted exon encoded the majority of the protein including the pore- and membrane-spanning domains and the entire N-terminal region and a substantial portion of the C-terminal region. Protein was undetected by Western blot analysis of homozygous mutant brain tissue. (J:77047)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnj9 Mutation: 31 strains or lines available

References

• Original: J:77047 Torrecilla M, et al., G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. J Neurosci. 2002 Jun 1;22(11):4328-34
• All: 20 reference(s)