Sp4^tm1Krc
Targeted Allele Detail

Summary

• Symbol: Sp4^tm1Krc
• Name: trans-acting transcription factor 4; targeted mutation 1, Kenneth R Chien
• MGI ID: MGI:2676622
• Synonyms: HF-1b^-
• Gene: Sp4 Location: Chr12:118198668-118265175 bp, - strand Genetic Position: Chr12, 63.48 cM
• Alliance: Sp4^tm1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77375
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing lacZ and neo was inserted in exon 1 via homologous recombination, replacing the codon regions of exons 1 and 2 and a portion of exon 3. Normal transcript was undetected by Northern blot analysis of homozygous mutant mice. (J:77375)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp4 Mutation: 35 strains or lines available

References

• Original: J:77375 Nguyen-Tran VT, et al., A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Cell. 2000 Sep 1;102(5):671-82
• All: 4 reference(s)