Pde1b^tm1Cvv
Targeted Allele Detail

Summary

• Symbol: Pde1b^tm1Cvv
• Name: phosphodiesterase 1B, Ca2+-calmodulin dependent; targeted mutation 1, Charles V Vorhees
• MGI ID: MGI:2676625
• Synonyms: PDE1B^-
• Gene: Pde1b Location: Chr15:103411461-103438479 bp, + strand Genetic Position: Chr15, 58.99 cM
• Alliance: Pde1b^tm1Cvv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77514
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 through 9 have been replaced with a PGK-HPRT cassette disrupting sequences encoding the catalytic domain. Northern blot analysis demonstrated that mRNA transcripts of this allele were not present in RNA extracted from brains of homozygotes. (J:77514)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde1b Mutation: 49 strains or lines available

References

• Original: J:77514 Reed TM, et al., Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. J Neurosci. 2002 Jun 15;22(12):5188-97
• All: 2 reference(s)