Sh2d2a^tm1Jbs
Targeted Allele Detail

Summary

• Symbol: Sh2d2a^tm1Jbs
• Name: SH2 domain containing 2A; targeted mutation 1, Jeffrey Bluestone
• MGI ID: MGI:2676915
• Synonyms: RIBP KO, TSAd-
• Gene: Sh2d2a Location: Chr3:87754062-87763029 bp, + strand Genetic Position: Chr3, 38.78 cM
• Alliance: Sh2d2a^tm1Jbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64938
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4, which encode the SH2 domain, were replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of activated splenocytes obtained from homozygous mutant mice. (J:64938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d2a Mutation: 20 strains or lines available

References

• Original: J:64938 Rajagopal K, et al., RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. J Exp Med. 1999 Dec 6;190(11):1657-68
• All: 13 reference(s)