Glra1^tm1Rah
Targeted Allele Detail

Summary

• Symbol: Glra1^tm1Rah
• Name: glycine receptor, alpha 1 subunit; targeted mutation 1, R Adron Harris
• MGI ID: MGI:2676917
• Gene: Glra1 Location: Chr11:55405065-55499024 bp, - strand Genetic Position: Chr11, 33.12 cM
• Alliance: Glra1^tm1Rah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85341
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: Exon 7 was modified so that the codon for serine at amino acid position 267 (AGC) changed to one that codes for glutamine (CAG) (S267Q). At the same time, a neomycin resistance gene flanked by FLP recombinase target sites was inserted. F1 heterozygotes were mated to FLP general deleter mice to remove the neo marker gene. (J:85341)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glra1 Mutation: 30 strains or lines available

References

• Original: J:85341 Findlay GS, et al., Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant. J Neurosci. 2003 Sep 3;23(22):8051-9
• All: 1 reference(s)