Tg(SMN2)566Ahmb
Transgene Detail

Summary

• Symbol: Tg(SMN2)566Ahmb
• Name: transgene insertion 566, Arthur H M Burghes
• MGI ID: MGI:2676920
• Transgene: Tg(SMN2)566Ahmb Location: unknown
• Alliance: Tg(SMN2)566Ahmb page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SMN2)566Ahmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SMN2 (6607)

  Smn1	(MGI:109257)

• Mutation details: A 35.5 kb genomic fragment containing human SMN2 used for the transgene. The transgene is ubiquitously expressed in all tissues examined by Northern blot analysis. Line 566 carries 8 copies of the transgene. (J:60592)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Line 89 was also produced.

References

• Original: J:60592 Monani UR, et al., The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet. 2000 Feb 12;9(3):333-9
• All: 4 reference(s)