Thrb^tm4Few
Targeted Allele Detail

Summary

• Symbol: Thrb^tm4Few
• Name: thyroid hormone receptor beta; targeted mutation 4, Frederic E Wondisford
• MGI ID: MGI:2676951
• Synonyms: TR-Beta^-, TRbetaKO
• Gene: Thrb Location: Chr14:4431611-4809435 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
• Alliance: Thrb^tm4Few page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85158
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a self-excising PGK-neo cassette. The deletion of exon 3 putatively results in an aberrant open reading frame caused by the fusion of exons 2 and 4. Using a C-terminal mAb, protein was undetected by Western blot analysis of homozygous mutant mice. (J:85158)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thrb Mutation: 41 strains or lines available

References

• Original: J:85158 Shibusawa N, et al., Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest. 2003 Aug;112(4):588-97
• All: 3 reference(s)