Pea15a^tm1Chne
Targeted Allele Detail

Summary

• Symbol: Pea15a^tm1Chne
• Name: proliferation and apoptosis adaptor protein 15A; targeted mutation 1, Herve Chneiweiss
• MGI ID: MGI:2677021
• Synonyms: PEA-15-
• Gene: Pea15a Location: Chr1:172024295-172034298 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Pea15a^tm1Chne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77283
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.5 kb fragment encompassing the entire coding region was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of astrocytes derived from homozygous mutant mice. The absence of protein was verified by 2D-PAGE. (J:77283)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pea15a Mutation: 14 strains or lines available

References

• Original: J:77283 Kitsberg D, et al., Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. J Neurosci. 1999 Oct 1;19(19):8244-51
• All: 8 reference(s)