Myb^tm1Jof
Targeted Allele Detail

Summary

• Symbol: Myb^tm1Jof
• Name: myeloblastosis oncogene; targeted mutation 1, Jon Frampton
• MGI ID: MGI:2677048
• Synonyms: c-myb^KD, c-Myb^loxP, c-myb^lx
• Gene: Myb Location: Chr10:21000834-21036883 bp, - strand Genetic Position: Chr10, 9.75 cM
• Alliance: Myb^tm1Jof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85344
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted upstream of exon 3 and downstream of exon 6. In addition, an FRT flanked PGK-neo cassette was inserted in intron 6. The neomycin insertion resulted in underexpression of the gene (5-10% normal) as indicated by western blot analysis. (J:85344)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myb Mutation: 53 strains or lines available

References

• Original: J:85344 Emambokus N, et al., Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J. 2003 Sep 1;22(17):4478-88
• All: 5 reference(s)