Vpreb1b^tm1Shim
Targeted Allele Detail

Summary

• Symbol: Vpreb1b^tm1Shim
• Name: V-set pre-B cell surrogate light chain 1B; targeted mutation 1, Takeyuki Shimizu
• MGI ID: MGI:2677165
• Synonyms: VpreB2^-
• Gene: Vpreb1b Location: Chr16:17798292-17799137 bp, + strand Genetic Position: Chr16, 11.14 cM
• Alliance: Vpreb1b^tm1Shim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76947
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene was replaced with a hygromycin resistance gene and single adjacent loxP site in ES cells in which Vpreb1 and Igl5 had already been disrupted. Absence of mRNA transcripts was established by PCR. (J:76947)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vpreb1b Mutation: 8 strains or lines available

References

• Original: J:76947 Shimizu T, et al., VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J Immunol. 2002 Jun 15;168(12):6286-93
• All: 3 reference(s)