Igll1^tm1Shim
Targeted Allele Detail

Summary

• Symbol: Igll1^tm1Shim
• Name: immunoglobulin lambda-like polypeptide 1; targeted mutation 1, Takeyuki Shimizu
• MGI ID: MGI:2677170
• Synonyms: lambda 5-
• Gene: Igll1 Location: Chr16:16678535-16681849 bp, - strand Genetic Position: Chr16, 10.45 cM
• Alliance: Igll1^tm1Shim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76947
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Exon 1 of this gene as well as the entire VpreB1 gene were replaced with a neomycin resistance gene flanked by loxP sites. mRNA transcripts of this gene were not detected by Northern blot analysis but small amounts of a truncated product containing sliced exons 2 and 3 could be detected by PCR. No protein product was predicted from this mRNA. All mRNA product could be eliminated by cre mediated excision of the neomycin insert but this had no ultimate effect on the observed phenotypes. (J:76947)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igll1 Mutation: 16 strains or lines available

References

• Original: J:76947 Shimizu T, et al., VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J Immunol. 2002 Jun 15;168(12):6286-93
• All: 5 reference(s)